Treatment of lymphosarcoma in the dog with L-asparaginase

L-asparaginase in treatment of acute leukaemia and lymphosarcoma.

L-Asparaginase was used to treat 40 patients with acute leukaemia or lymphosarcoma. Fifteen with acute lymphoblastic leukaemia either untreated or in relapse after previous therapy were given "Squibb," "Bayer," or "Porton" L-asparaginase. Five of these patients had complete remission of their disease, and four had good partial remission. Eleven patients with acute myeloid leukaemia were treated...

modern surgical techniques in treatment of patients with cleft lip & cleft palate

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Inhibition of thymidine and basic amino acid metabolism in P1798 lymphosarcoma by L-asparaginase.

In vivo metabolism of lysine and arginine is markedly inhibited (p < 0.025) in P1798 lymphosarcoma within 1 hr after intraperitoneal injection of 1 unit of Escherichia coli L-asparaginase II. Two hr after treatment, there is substan tial inhibition of thymidine transport but no effect on incorporation of thymidine. None of these effects were observed in the L-asparaginase-resistant subline of t...

L-asparaginase in the treatment of neoplastic diseases in children.

In vivo and in vitro effects of the L-asparaginase fraction of guinea pig serum on the 6C3HED ascites lymphosarcoma.

The antitumor activity of guinea 1'ig serum fractions was studied in vivo and in vitro by bright field, fluorescence, and electron microscopy observations and by dye permeability and cytidine-3H incorporation in 6C3HED lymphosarcoma cells. In C3H mice bearing the ascites tumor treated with the Lasparaginase fraction, there was a decrease in the total num ber and mitosis of tumor cells, a reduct...